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Details on Person Phosphorylation of SHC1 by p-5Y-EGFRvIII

Class:Id	Reaction:5637796
_displayName	Phosphorylation of SHC1 by p-5Y-EGFRvIII
_doRelease	TRUE
_timestamp	2018-02-20 14:45:39
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:9037672] protein tyrosine kinase activity of p-5Y-EGFRvIII:SHC1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5637797] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9037674] gain_of_function of p-5Y-EGFRvIII:SHC1 [plasma membrane]
input	[Complex:5637701] p-5Y-EGFRvIII:SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:180308] Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites [LiteratureReference:180313] Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2
modified	[InstanceEdit:9037675] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SHC1 by p-5Y-EGFRvIII
normalReaction	[Reaction:177933] SHC1 phosphorylation by phosphorylated EGFR [Homo sapiens]
output	[Complex:5637703] p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants [Homo sapiens] [Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens] [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6781722] R-HSA-5637796.3
summation	[Summation:5637786] EGFRvIII cancer mutant was not directly tested for its abili...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
(precedingEvent)	[Reaction:5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780066] Update Tracker - [Reaction:5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII - v64:[add_removeCatalystActivity]
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