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Details on Person Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant

Class:Id	Reaction:5637795
_displayName	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
_doRelease	TRUE
_timestamp	2018-11-29 15:09:51
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:5637709] protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5637797] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630162] gain_of_function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:5637698] p-5Y-EGFRvIII:PLCG1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
modified	[InstanceEdit:9630164] Orlic-Milacic, Marija, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
normalReaction	[Reaction:212710] EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens]
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:5637706] p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5637792] PLC-gamma 1 binds to p-EGFRvIII mutant [Homo sapiens] [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644326] R-HSA-5637795.3
summation	[Summation:5637780] Once recruited, PLC-gamma 1 is assumed to be phosphorylated ...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
(precedingEvent)	[Reaction:5637800] Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant [Homo sapiens]
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