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Details on Person Binding of GRB2:GAB1 complex to p-EGFRvIII mutant

Class:Id	Reaction:5637764
_displayName	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant
_doRelease	TRUE
_timestamp	2018-11-28 19:29:29
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5637769] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5638131] gain_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
input	[Complex:1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane] [Homo sapiens] [Complex:179849] GRB2:GAB1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248643] Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
modified	[InstanceEdit:5638133] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9630102] Orlic-Milacic, Marija, 2018-11-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant
normalReaction	[Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR [Homo sapiens]
output	[Complex:5637694] p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers [Homo sapiens] [Reaction:1248002] Ligand-independent dimerization of EGFRvIII mutant [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622859] R-HSA-5637764.3
summation	[Summation:5637768] Direct binding of the GRB2:GAB1 complex to phosphorylated ho...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
(precedingEvent)	[Reaction:5637765] Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778539] Update Tracker - [Reaction:5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant - v68:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (5637764)