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Details on Person WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)

Class:Id	Reaction:5637686
_displayName	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)
_doRelease	TRUE
_timestamp	2022-12-19 15:22:07
authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:5637674] histone H3 methyltransferase activity of WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5637682] Jupe, Steve, 2014-11-12
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
input	[CandidateSet:5173296] MeK5-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5637676] Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity [LiteratureReference:5244752] MLL associates specifically with a subset of transcriptionally active target genes [LiteratureReference:5244699] Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus [LiteratureReference:5244751] Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus [LiteratureReference:5244753] Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases [LiteratureReference:4687068] PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex [LiteratureReference:5244703] Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 [LiteratureReference:5637680] SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
modified	[InstanceEdit:5638142] Jupe, Steve, 2014-11-13 [InstanceEdit:5638320] Jupe, Steve, 2014-11-13 [InstanceEdit:5643672] Jupe, Steve, 2014-11-17 [InstanceEdit:5643684] Jupe, Steve, 2014-11-17 [InstanceEdit:5674415] Jupe, Steve, 2015-02-12 [InstanceEdit:5674563] Jupe, Steve, 2015-02-13 [InstanceEdit:5676065] Jupe, Steve, 2015-02-19 [InstanceEdit:9822169] Orlic-Milacic, Marija, 2022-12-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate MeK5-histone H3 WHSC1L1, Core MLL complex, SMYD3 methylate MeK5-histone H3
output	[CandidateSet:5244740] Me2K5-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9675026] Formation of the MLL1 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [BlackBoxEvent:9818576] Cleaved KMT2A dimers translocate to the nucleus [Homo sapiens] [Reaction:9676255] Formation of the MLL2 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [BlackBoxEvent:9818578] Cleaved KMT2B dimers translocate to the nucleus [Homo sapiens] [Reaction:9676254] Formation of the MLL3 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:9676268] Formation of the MLL4 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:9676257] Formation of the SET1A complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:9676264] Formation of the SET1B complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) [Homo sapiens] [Reaction:9675026] Formation of the MLL1 complex [Homo sapiens] [Reaction:9676255] Formation of the MLL2 complex [Homo sapiens] [Reaction:9676254] Formation of the MLL3 complex [Homo sapiens] [Reaction:9676268] Formation of the MLL4 complex [Homo sapiens] [Reaction:9676257] Formation of the SET1A complex [Homo sapiens] [Reaction:9676264] Formation of the SET1B complex [Homo sapiens]
releaseDate	2015-03-15
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644739] R-HSA-5637686.3
summation	[Summation:5244702] Trimethylation of lysine-5 of histone H3 (H3K4) has been lin...
(hasEvent)	[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
(precedingEvent)	[Reaction:5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784574] Update Tracker - [Reaction:5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - v53:[modifyText] [_UpdateTracker:9784940] Update Tracker - [Reaction:5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - v52:[modifyText]
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No pathways have been reviewed or authored by WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (5637686)