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Details on Person NUMB:ITCH binds GLI1

Class:Id	Reaction:5635861
_displayName	NUMB:ITCH binds GLI1
_doRelease	TRUE
_timestamp	2018-01-23 22:46:08
authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5635862] Rothfels, Karen, 2014-11-07
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[EntityWithAccessionedSequence:445457] GLI1 [cytosol] [Homo sapiens] [Complex:5610562] NUMB:ITCH [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5609813] Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal [LiteratureReference:5609824] Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination [LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation
modified	[InstanceEdit:5636044] Rothfels, Karen, 2014-11-09 [InstanceEdit:9035504] Rothfels, Karen, 2018-01-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NUMB:ITCH binds GLI1
output	[Complex:5635832] GLI1:NUMB:ITCH [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5610735] NUMB binds ITCH [Homo sapiens] [BlackBoxEvent:5635853] Hh-dependent expression of GLI1 gene [Homo sapiens] [Reaction:5635846] GLI proteins bind GLI1 gene [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644355] R-HSA-5635861.3
summation	[Summation:5635797] GLI1 is recruited to the NUMB:ITCH complex through a direct ...
(hasEvent)	[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
(precedingEvent)	[Reaction:5635864] NUMB:ITCH ubiquitinates GLI1 [Homo sapiens]
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No pathways have been reviewed or authored by NUMB:ITCH binds GLI1 (5635861)