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Details on Person phosphorylated GLI proteins bind SPOP:CUL3:RBX1

Class:IdReaction:5635855
_displayNamephosphorylated GLI proteins bind SPOP:CUL3:RBX1
_doReleaseTRUE
_timestamp2014-11-20 02:35:15
authored[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5635857] Rothfels, Karen, 2014-11-07
edited[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input[Complex:5635071] SPOP:CUL3:RBX1 [nucleoplasm] [Homo sapiens]
[DefinedSet:5635080] 2p-GLI2,3 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
[LiteratureReference:5634917] Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
[LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
[LiteratureReference:5610143] Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
[LiteratureReference:5634936] Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
[LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
[LiteratureReference:216263] A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
[LiteratureReference:216191] Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
[LiteratureReference:976142] Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases
[LiteratureReference:5634968] Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases
[LiteratureReference:5634996] The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling
[LiteratureReference:5635003] iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
[LiteratureReference:5634981] The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis
[LiteratureReference:5634910] Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
[LiteratureReference:5634986] The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis
[LiteratureReference:5634893] Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis
[LiteratureReference:5634984] The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1
[LiteratureReference:5634951] Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling
modified[InstanceEdit:5636059] Rothfels, Karen, 2014-11-09
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namephosphorylated GLI proteins bind SPOP:CUL3:RBX1
output[Complex:5635087] 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:5635873] Positive regulation by 'DZIP1 [nucleoplasm]'
releaseDate2014-12-11
reviewed[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644364] R-HSA-5635855.3
summation[Summation:5635805] Full-length GLI proteins are labile transcription factors th...
(hasEvent)[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
(precedingEvent)[Reaction:5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 [Homo sapiens]
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No pathways have been reviewed or authored by phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (5635855)
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