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Details on Person GLI2,3 are degraded by the proteasome

Class:Id	BlackBoxEvent:5635854
_displayName	GLI2,3 are degraded by the proteasome
_doRelease	TRUE
_timestamp	2014-11-20 02:33:09
authored	[InstanceEdit:5634978] Rothfels, Karen, 2014-11-06
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5635857] Rothfels, Karen, 2014-11-07
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[Complex:5635095] ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5634936] Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase [LiteratureReference:5610143] Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved [LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
modified	[InstanceEdit:5635910] Rothfels, Karen, 2014-11-07 [InstanceEdit:5636033] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI2,3 are degraded by the proteasome
output	[Complex:5635071] SPOP:CUL3:RBX1 [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 [Homo sapiens] [Reaction:5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622718] R-HSA-5635854.2
summation	[Summation:5635785] SPOP:CUL3:RBX1-mediated ubiquitination of the transcriptiona...
(hasEvent)	[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
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No pathways have been reviewed or authored by GLI2,3 are degraded by the proteasome (5635854)