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Details on Person Hh-dependent expression of GLI1 gene

Class:Id	BlackBoxEvent:5635853
_displayName	Hh-dependent expression of GLI1 gene
_doRelease	TRUE
_timestamp	2014-11-20 02:43:46
authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:5635852] Rothfels, Karen, 2014-11-07
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[EntityWithAccessionedSequence:5617393] GLI1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5634889] All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 [LiteratureReference:5609748] Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway [LiteratureReference:5609839] Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
modified	[InstanceEdit:5636042] Rothfels, Karen, 2014-11-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh-dependent expression of GLI1 gene
output	[EntityWithAccessionedSequence:445457] GLI1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5635846] GLI proteins bind GLI1 gene [Homo sapiens] [BlackBoxEvent:5635841] GLI proteins are phosphorylated [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5635870] Positive gene expression regulation by '2p-GLI:GLI1 gene [nucleoplasm]'
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644672] R-HSA-5635853.3
summation	[Summation:5635800] GLI1 expression is promoted by the binding of the full-lengt...
(hasEvent)	[Pathway:5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription [Homo sapiens]
(precedingEvent)	[Reaction:5635861] NUMB:ITCH binds GLI1 [Homo sapiens]
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No pathways have been reviewed or authored by Hh-dependent expression of GLI1 gene (5635853)