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Details on Person ULK3 phosphorylates GLI

Class:Id	Reaction:5635842
_displayName	ULK3 phosphorylates GLI
_doRelease	TRUE
_timestamp	2018-01-23 22:45:44
authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
catalystActivity	[CatalystActivity:5635824] protein serine/threonine kinase activity of ULK3 [ciliary tip]
compartment	[Compartment:5263228] ciliary tip
created	[InstanceEdit:5635840] Rothfels, Karen, 2014-11-07
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[DefinedSet:5621782] GLI1,2,3 [ciliary tip] [Homo sapiens] [SimpleEntity:5632460] ATP [cilium]
isChimeric	FALSE
literatureReference	[LiteratureReference:5634898] Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway [LiteratureReference:5634918] Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway [LiteratureReference:5634927] Mammalian homologues of Drosophila fused kinase [LiteratureReference:5634920] Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction [LiteratureReference:3769231] Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling [LiteratureReference:5634937] Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 [LiteratureReference:5610134] Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling
modified	[InstanceEdit:5636057] Rothfels, Karen, 2014-11-09 [InstanceEdit:9035499] Rothfels, Karen, 2018-01-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ULK3 phosphorylates GLI
output	[DefinedSet:5635089] p-GLI1,2,3 [ciliary tip] [Homo sapiens] [SimpleEntity:5632457] ADP [cilium]
precedingEvent	[Reaction:5635839] ULK3:SUFU dissociates [Homo sapiens] [Reaction:5635859] GLI:SUFU dissociates [Homo sapiens] [BlackBoxEvent:5635860] GLI:SUFU translocates to the ciliary tip in response to Hh signaling [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644954] R-HSA-5635842.3
summation	[Summation:5635812] Dissociation from SUFU allows the STK36/dFu homologue ULK3 t...
(hasEvent)	[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5635843] GLI translocates to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by ULK3 phosphorylates GLI (5635842)