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Details on Person GLI proteins are phosphorylated

Class:Id	BlackBoxEvent:5635841
_displayName	GLI proteins are phosphorylated
_doRelease	TRUE
_timestamp	2014-11-20 02:52:15
authored	[InstanceEdit:5633209] Rothfels, Karen, 2014-10-30
catalystActivity	[CatalystActivity:5635827] protein serine/threonine kinase activity of unknown kinase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5635840] Rothfels, Karen, 2014-11-07
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[DefinedSet:5635090] p-GLI1,2,3 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:5634920] Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction [LiteratureReference:5634918] Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway [LiteratureReference:5634898] Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway [LiteratureReference:5634927] Mammalian homologues of Drosophila fused kinase [LiteratureReference:5634937] Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 [LiteratureReference:5635772] DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS [LiteratureReference:5610134] Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis [LiteratureReference:5610143] Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved [LiteratureReference:5634936] Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
modified	[InstanceEdit:5636026] Rothfels, Karen, 2014-11-09 [InstanceEdit:5638359] Rothfels, Karen, 2014-11-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI proteins are phosphorylated
output	[DefinedSet:5635077] 2p-GLI1,2,3 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:5635843] GLI translocates to the nucleus [Homo sapiens] [Reaction:5635842] ULK3 phosphorylates GLI [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645005] R-HSA-5635841.2
summation	[Summation:5635791] Hh signaling induces phosphorylation of full-length GLI that...
(hasEvent)	[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
(precedingEvent)	[Reaction:5635845] GLI proteins bind CDC73 [Homo sapiens] [Reaction:5635846] GLI proteins bind GLI1 gene [Homo sapiens] [Reaction:5635848] GLI proteins bind PTCH1 gene [Homo sapiens] [Reaction:5635850] GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters [Homo sapiens] [Reaction:5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 [Homo sapiens] [Reaction:8986294] RUNX2 binds GLI2 [Homo sapiens]
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No pathways have been reviewed or authored by GLI proteins are phosphorylated (5635841)