Query author contributions in Reactome
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Details on Person GLI1 is recruited to the NUMB:ITCH complex through a direct ...
| Class:Id | Summation:5635797 |
|---|---|
| _displayName | GLI1 is recruited to the NUMB:ITCH complex through a direct ... |
| _timestamp | 2014-11-07 17:24:31 |
| created | [InstanceEdit:5635796] Rothfels, Karen, 2014-11-07 |
| text | GLI1 is recruited to the NUMB:ITCH complex through a direct interaction with both proteins. Once recruited, GLI1 is ubiquitinated by ITCH and subsequently degraded by the proteasome. ITCH-mediated degradation of GLI1 does not depend on the Dc or Dn degrons required for interaction with beta-TrCP, but instead relies on a novel PPXYs/pSP degron of GLI1 (di Marcotullio et al, 2006, 2011; Huntzicker et al, 2006). |
| (summation) | [Reaction:5635861] NUMB:ITCH binds GLI1 [Homo sapiens] |
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No pathways have been reviewed or authored by GLI1 is recruited to the NUMB:ITCH complex through a direct ... (5635797)
