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Details on Person GPR161 is internalized

Class:Id	BlackBoxEvent:5635102
_displayName	GPR161 is internalized
_doRelease	TRUE
_timestamp	2014-11-20 02:39:41
authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
compartment	[Compartment:261122] ciliary membrane [Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:5635101] Rothfels, Karen, 2014-11-06
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[EntityWithAccessionedSequence:5610373] GPR161 [ciliary membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium [LiteratureReference:5610304] TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia [LiteratureReference:5610306] The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling [LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5610180] G-protein-coupled receptors, Hedgehog signaling and primary cilia
modified	[InstanceEdit:5636036] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GPR161 is internalized
output	[EntityWithAccessionedSequence:5635021] GPR161 [endocytic vesicle membrane] [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644518] R-HSA-5635102.2
summation	[Summation:5635100] Hh signaling promotes the removal of the orphan G protein co...
(hasEvent)	[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
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No pathways have been reviewed or authored by GPR161 is internalized (5635102)