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Query author contributions in Reactome

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Details on Person EHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromati...

Class:IdSummation:5634757
_displayNameEHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromati...
_timestamp2015-01-30 14:56:58
created[InstanceEdit:5634764] Jupe, Steve, 2014-11-06
literatureReference[LiteratureReference:3301891] G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
[LiteratureReference:427757] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
[LiteratureReference:3788732] Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
[LiteratureReference:5669113] Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP
[LiteratureReference:5634756] H3K9 methyltransferase G9a and the related molecule GLP
modified[InstanceEdit:5634766] Jupe, Steve, 2014-11-06
[InstanceEdit:5669142] Jupe, Steve, 2015-01-30
textEHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromatic histone H3 lysine-10 (H3K9) mono and di-methyltransferases in mammals (Tachibana et al. 2002, Rice et al. 2003, Tachibana et al. 2005). In vivo they exist predominantly as a heteromeric complex together with WIZ, a multi-zinc finger protein, (Ueda et al. 2006) and are responsible for global H3K9 mono- and di-methylation (Shinkai & Tchibana 2011).
(summation)[Reaction:5634750] EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) [Homo sapiens]
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