Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:K9JA28-1 IFNLR1
| Class:Id | ReferenceIsoform:5634245 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-567 added on Fri February 6 2015 |
| _displayName | UniProt:K9JA28-1 IFNLR1 |
| _timestamp | 2023-11-03 16:22:29 |
| chain | signal peptide:1-22 chain:23-567 |
| checksum | 0E5AE2A73DB3DB4A |
| comment | FUNCTION The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.SUBUNIT Heterodimer with IL10RB.SUBCELLULAR LOCATION Belongs to the type II cytokine receptor family. |
| created | [InstanceEdit:5634237] Weiser, JD |
| description | recommendedName: Interferon lambda receptor 1 shortName: IFN-lambda R1 alternativeName: Cytokine receptor class-II member 12 alternativeName: Cytokine receptor family 2 member 12 shortName: CRF2-12 alternativeName: Interleukin-28 receptor subunit alpha shortName: IL-28 receptor subunit alpha shortName: IL-28R-alpha shortName: IL-28RA |
| geneName | IFNLR1 IL28RA |
| identifier | K9JA28 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Antiviral defense Disulfide bond Glycoprotein Membrane Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | IFNLR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | INLR1_CHICK K9J9W8 W0FB28 |
| sequenceLength | 567 |
| species | [Species:49591] Gallus gallus |
| variantIdentifier | K9JA28-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:K9JA28-1 IFNLR1 (5634245)
