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Details on Person UniProt:G5EBR3 glc-1
| Class:Id | ReferenceGeneProduct:5634239 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21-461 added on Sat February 7 2015 |
| _displayName | UniProt:G5EBR3 glc-1 |
| _timestamp | 2023-11-03 15:02:37 |
| chain | signal peptide:1-20 chain:21-461 |
| checksum | 0F2388D1FAC0309F |
| comment | FUNCTION Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817). Plays a role in the regulation of locomotor behavior (PubMed:16527366).SUBUNIT Pentamer (PubMed:21572436, PubMed:25143115). Homooligomer, forms functional heterooligomers with glc-2 (PubMed:7935817).INTERACTION Glutamate binding is mediated by the extracellular domain. In contrast, the allosteric modulator ivermectin binds between subunits at the periphery of the transmembrane domain, proximal to the extracellular side.DISRUPTION PHENOTYPE RNAi-mediated knockdown causes a decrease in the duration of forward locomotion in the absence of food, and an increase in the frequency of turns.SIMILARITY Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily. |
| created | [InstanceEdit:5634237] Weiser, JD |
| description | recommendedName: fullName evidence="8"Glutamate-gated chloride channel alpha alternativeName: fullName evidence="7"Avermectin-sensitive glutamate-gated chloride channel GluCl alpha alternativeName: fullName evidence="8"GluCl alpha |
| geneName | glc-1 F11A5.10 |
| identifier | G5EBR3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Chloride Disulfide bond Glycoprotein Ion channel Ion transport Membrane Postsynaptic cell membrane Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | glc-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GLUCL_CAEEL |
| sequenceLength | 461 |
| species | [Species:68320] Caenorhabditis elegans |
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No pathways have been reviewed or authored by UniProt:G5EBR3 glc-1 (5634239)
