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Details on Person TRAF1 binds TRAF2 within TNFR1 signaling complex

Class:Id	Reaction:5634221
_displayName	TRAF1 binds TRAF2 within TNFR1 signaling complex
_doRelease	TRUE
_timestamp	2015-09-04 20:30:16
authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5634222] Shamovsky, V, 2014-11-03
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
input	[EntityWithAccessionedSequence:168651] RIPK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5634163] TRAF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens] [DefinedSet:3371401] TNF-α trimer:TNFR1 trimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5357891] Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation [LiteratureReference:5657914] Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death
modified	[InstanceEdit:5657926] Shamovsky, V, 2014-12-16 [InstanceEdit:5661500] Shamovsky, V, 2015-01-12 [InstanceEdit:5692571] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5693173] Shamovsky, Veronica, 2015-05-14 [InstanceEdit:5693832] Shamovsky, Veronica, 2015-05-18 [InstanceEdit:5693863] Shamovsky, Veronica, 2015-05-18 [InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF1 binds TRAF2 within TNFR1 signaling complex
output	[Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796646] R-HSA-5634221.2
summation	[Summation:5657915] TNF-induced NFkappaB activates a group of gene products incl...
(hasEvent)	[Pathway:5357905] Regulation of TNFR1 signaling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846998] Update Tracker - [Reaction:5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex - v82:[modifyText]
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