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Details on Person TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]

Class:Id	Complex:5634184
_displayName	TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]
_timestamp	2015-09-04 18:42:34
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5634186] Shamovsky, V, 2014-11-03
hasComponent	[EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5634163] TRAF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168651] RIPK1 [cytosol] [Homo sapiens] [DefinedSet:3371401] TNF-α trimer:TNFR1 trimer [plasma membrane] [Homo sapiens]
includedLocation	[Compartment:70101] cytosol
isChimeric	FALSE
literatureReference	[LiteratureReference:5634189] TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways [LiteratureReference:5634185] TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex [LiteratureReference:5357891] Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation
modified	[InstanceEdit:5661499] Shamovsky, V, 2015-01-12
name	TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6794926] R-HSA-5634184.1
(hasMember)	[DefinedSet:5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane] [Homo sapiens]
(output)	[Reaction:5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex [Homo sapiens] [Reaction:5634230] TRAF1(164-416) binds TRAF2 within TNFR1 signaling complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9894573] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v57:[updateContainedComponent] [_UpdateTracker:9903018] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v80:[updateContainedComponent] [_UpdateTracker:9904389] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v82:[updateContainedComponent] [_UpdateTracker:9928631] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v91:[updateContainedComponent]
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No pathways have been reviewed or authored by TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (5634184)