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Details on Person MDM2 binds TP53

Class:Id	Reaction:5633460
_displayName	MDM2 binds TP53
_doRelease	TRUE
_timestamp	2022-02-22 12:56:39
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5633454] Orlic-Milacic, Marija, 2014-10-31
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:3209194] TP53 Tetramer [nucleoplasm] [Homo sapiens] [DefinedSet:6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5633458] The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation [LiteratureReference:5633467] Amplification of a gene encoding a p53-associated protein in human sarcomas [LiteratureReference:5633461] Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 [LiteratureReference:5633453] Mapping of the p53 and mdm-2 interaction domains [LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage [LiteratureReference:6804878] HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
modified	[InstanceEdit:6795671] Orlic-Milacic, Marija, 2015-09-04 [InstanceEdit:6804755] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:6804881] Orlic-Milacic, Marija, 2015-10-15 [InstanceEdit:6804886] Orlic-Milacic, Marija, 2015-10-15 [InstanceEdit:6806090] Orlic-Milacic, Marija, 2015-10-21 [InstanceEdit:8856342] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8932785] Orlic-Milacic, Marija, 2016-07-28 [InstanceEdit:8932867] Orlic-Milacic, Marija, 2016-07-29 [InstanceEdit:8979252] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MDM2 binds TP53
negativePrecedingEvent	[NegativePrecedingEvent:9766479] Futile Cycle: MDM2 ubiquitinates TP53
output	[Complex:6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6804741] MDM2 forms homo- or heterodimers [Homo sapiens] [Reaction:6793666] MDM2 translocates to the nucleus [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [BlackBoxEvent:6804188] PRDM1 represses TP53 expression [Homo sapiens]
regulatedBy	[NegativeRegulation:8979263] Negative regulation by 'PHF20 [nucleoplasm]'
regulationReference	[RegulationReference:9641991] Negative regulation by 'PHF20 [nucleoplasm]' PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860887] R-HSA-5633460.7
summation	[Summation:5633465] The N-terminal portion of MDM2 binds the N-terminal transact...
(hasEvent)	[Pathway:69541] Stabilization of p53 [Homo sapiens] [Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(precedingEvent)	[Reaction:6804879] MDM2 ubiquitinates TP53 [Homo sapiens] [Reaction:6804998] p14ARF forms a ternary complex with MDM2 and TP53 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781585] Update Tracker - [Reaction:5633460] MDM2 binds TP53 - v60:[addRegulator]
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