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Details on Person EFCAB7:IQCE binds EVC2:EVC

Class:Id	Reaction:5633051
_displayName	EFCAB7:IQCE binds EVC2:EVC
_doRelease	TRUE
_timestamp	2014-11-20 02:33:28
authored	[InstanceEdit:5632699] Rothfels, Karen, 2014-10-28
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5633054] Rothfels, Karen, 2014-10-29
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[Complex:5633045] EFCAB7:IQCE [cilium] [Homo sapiens] [Complex:5633041] EVC2:EVC [ciliary membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5629111] EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia [LiteratureReference:5628961] A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia [LiteratureReference:5629140] The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia [LiteratureReference:5633044] Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus
modified	[InstanceEdit:5633067] Rothfels, Karen, 2014-10-29 [InstanceEdit:5636023] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EFCAB7:IQCE binds EVC2:EVC
output	[Complex:5633050] IQCE:EFCAB7:EVC2:EVC [ciliary membrane] [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622696] R-HSA-5633051.2
summation	[Summation:5633052] IQCE and EFCAB7 are ciliary proteins that are required to re...
(hasEvent)	[Pathway:5635838] Activation of SMO [Homo sapiens]
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No pathways have been reviewed or authored by EFCAB7:IQCE binds EVC2:EVC (5633051)