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Details on Person TP53 stimulates transcription of RRM2B gene

Class:Id	BlackBoxEvent:5632892
_displayName	TP53 stimulates transcription of RRM2B gene
_doRelease	TRUE
_timestamp	2017-02-23 15:16:42
authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5632891] Orlic-Milacic, Marija, 2014-10-29
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
input	[EntityWithAccessionedSequence:5632883] RRM2B Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:111775] A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage [LiteratureReference:5632908] Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion [LiteratureReference:5632896] p53 regulates mtDNA copy number and mitocheckpoint pathway
modified	[InstanceEdit:5632910] Orlic-Milacic, Marija, 2014-10-29 [InstanceEdit:5662797] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662805] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662838] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5674607] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:8856013] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8979246] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates transcription of RRM2B gene
output	[EntityWithAccessionedSequence:111792] RRM2B [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5632887] TP53 binds the RRM2B gene [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5632893] Positive gene expression regulation by 'TP53 Tetramer:RRM2B Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642131] Positive gene expression regulation by 'TP53 Tetramer:RRM2B Gene [nucleoplasm]' A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
releaseDate	2015-03-19
releaseStatus	UPDATED
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679715] R-HSA-5632892.6
summation	[Summation:5632900] TP53 (p53) directly stimulates transcription of RRM2B gene (...
(hasEvent)	[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(precedingEvent)	[Reaction:111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Homo sapiens] [Reaction:8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783587] Update Tracker - [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene - v56:[modifyText] [_UpdateTracker:9783919] Update Tracker - [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene - v55:[modifyText]
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No pathways have been reviewed or authored by TP53 stimulates transcription of RRM2B gene (5632892)