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Details on Person p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

Class:Id	Reaction:5632732
_displayName	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
_doRelease	TRUE
_timestamp	2016-02-29 20:27:20
authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5632733] Orlic-Milacic, Marija, 2014-10-28
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
input	[EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] [Homo sapiens] [DefinedSet:1445138] 14-3-3 dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5632730] 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s) [LiteratureReference:5632718] Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
modified	[InstanceEdit:5632746] Orlic-Milacic, Marija, 2014-10-28 [InstanceEdit:5662797] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662805] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662841] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5674607] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:8856007] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
output	[Complex:5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:198609] AKT phosphorylates TSC2, inhibiting it [Homo sapiens] [Reaction:198270] PDPK1 phosphorylates AKT at T308 [Homo sapiens]
regulatedBy	[NegativeRegulation:5632745] Negative regulation by 'DDIT4:14-3-3 dimer [cytosol]'
regulationReference	[RegulationReference:9642283] Negative regulation by 'DDIT4:14-3-3 dimer [cytosol]' p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage
releaseDate	2015-03-19
releaseStatus	UPDATED
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679996] R-HSA-5632732.5
summation	[Summation:5632729] Phosphorylation of TSC2 by AKT enables association of TSC2 w...
(hasEvent)	[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
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No pathways have been reviewed or authored by p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (5632732)