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Details on Person EVC2:EVC binds p-SMO

Class:Id	Reaction:5632679
_displayName	EVC2:EVC binds p-SMO
_doRelease	TRUE
_timestamp	2015-06-02 02:07:01
authored	[InstanceEdit:5629142] Rothfels, Karen, 2014-10-24
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632680] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
inferredFrom	[Reaction:5633169] Evc2:Evc binds Smo [Mus musculus]
input	[Complex:5632614] p6S, T-SMO dimer [ciliary membrane] [Homo sapiens] [Complex:5633041] EVC2:EVC [ciliary membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5633044] Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus [LiteratureReference:5628961] A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia [LiteratureReference:5629111] EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia [LiteratureReference:5629140] The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia [LiteratureReference:5629130] Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2
modified	[InstanceEdit:5633037] Rothfels, Karen, 2014-10-29 [InstanceEdit:5633124] Rothfels, Karen, 2014-10-30 [InstanceEdit:5633210] Rothfels, Karen, 2014-10-30 [InstanceEdit:5636024] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EVC2:EVC binds p-SMO
output	[Complex:5633039] p6S, T-SMO dimer:EVC2:EVC [ciliary membrane] [Homo sapiens]
precedingEvent	[Reaction:5633040] CSNK1A1 and ADRBK1 dissociate from p-SMO dimer [Homo sapiens] [Reaction:5632672] ADRBK1 phosphorylates SMO dimer [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6781717] R-HSA-5632679.2
summation	[Summation:5633123] EVC2 and EVC are components of a complex that localizes to t...
(hasEvent)	[Pathway:5635838] Activation of SMO [Homo sapiens]
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No pathways have been reviewed or authored by EVC2:EVC binds p-SMO (5632679)