Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person ADRBK1 binds phosphorylated SMO dimer

Class:Id	Reaction:5632674
_displayName	ADRBK1 binds phosphorylated SMO dimer
_doRelease	TRUE
_timestamp	2015-06-02 02:07:00
authored	[InstanceEdit:5632418] Rothfels, Karen, 2014-10-28
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632673] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
inferredFrom	[Reaction:5632663] Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1 [Mus musculus]
input	[Complex:5632624] pS588,S590, T593, S595-SMO dimer:CSNK1A1 [ciliary membrane] [Homo sapiens] [EntityWithAccessionedSequence:5632504] ADRBK1 [cilium] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5610283] Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened [LiteratureReference:5610169] G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:5632444] Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 [LiteratureReference:5632451] Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase
modified	[InstanceEdit:5636013] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ADRBK1 binds phosphorylated SMO dimer
output	[Complex:5632622] pS588, S590, T593, S595-SMO dimer:CSNK1A1:ADRBK1 [ciliary membrane] [Homo sapiens]
precedingEvent	[Reaction:5632670] CSNK1A1 phosphorylates SMO dimer [Homo sapiens] [Reaction:5632671] CSNK1A1 binds SMO dimer [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6781716] R-HSA-5632674.2
summation	[Summation:5632429] Initial binding and phosphorylation of the SMO C-terminal ta...
(hasEvent)	[Pathway:5635838] Activation of SMO [Homo sapiens]
(precedingEvent)	[Reaction:5632672] ADRBK1 phosphorylates SMO dimer [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by ADRBK1 binds phosphorylated SMO dimer (5632674)