Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person ADRBK1 phosphorylates SMO dimer

Class:Id	Reaction:5632672
_displayName	ADRBK1 phosphorylates SMO dimer
_doRelease	TRUE
_timestamp	2015-06-02 02:07:00
authored	[InstanceEdit:5629142] Rothfels, Karen, 2014-10-24
catalystActivity	[CatalystActivity:5632635] protein serine/threonine kinase activity of pS588, S590, T593, S595-SMO dimer:CSNK1A1:ADRBK1 [ciliary membrane]
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632673] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
inferredFrom	[Reaction:5632665] Adrbk1 phosphorylates Smo dimer [Mus musculus]
input	[Complex:5632622] pS588, S590, T593, S595-SMO dimer:CSNK1A1:ADRBK1 [ciliary membrane] [Homo sapiens] [SimpleEntity:5632460] ATP [cilium] [SimpleEntity:5632460] ATP [cilium] [SimpleEntity:5632460] ATP [cilium] [SimpleEntity:5632460] ATP [cilium] [SimpleEntity:5632460] ATP [cilium] [SimpleEntity:5632460] ATP [cilium]
isChimeric	FALSE
literatureReference	[LiteratureReference:5610283] Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened [LiteratureReference:5610169] G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5632444] Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 [LiteratureReference:5632451] Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase [LiteratureReference:208158] Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus [LiteratureReference:5618035] Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception [LiteratureReference:5610180] G-protein-coupled receptors, Hedgehog signaling and primary cilia [LiteratureReference:208072] Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2 [LiteratureReference:208191] Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 [LiteratureReference:216280] The ihog cell-surface proteins bind Hedgehog and mediate pathway activation
modified	[InstanceEdit:5635096] Rothfels, Karen, 2014-11-06 [InstanceEdit:5636014] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ADRBK1 phosphorylates SMO dimer
output	[Complex:5632615] p6S, T-SMO dimer:CSNK1A1:ADRBK1 [ciliary membrane] [Homo sapiens] [SimpleEntity:5632457] ADP [cilium] [SimpleEntity:5632457] ADP [cilium] [SimpleEntity:5632457] ADP [cilium] [SimpleEntity:5632457] ADP [cilium] [SimpleEntity:5632457] ADP [cilium] [SimpleEntity:5632457] ADP [cilium]
precedingEvent	[Reaction:5632674] ADRBK1 binds phosphorylated SMO dimer [Homo sapiens] [Reaction:5632670] CSNK1A1 phosphorylates SMO dimer [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6781715] R-HSA-5632672.2
summation	[Summation:5632400] ADRBK1 phosphorylates the SMO C-terminal tail after initial ...
(hasEvent)	[Pathway:5635838] Activation of SMO [Homo sapiens]
(precedingEvent)	[Reaction:5633040] CSNK1A1 and ADRBK1 dissociate from p-SMO dimer [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by ADRBK1 phosphorylates SMO dimer (5632672)