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Details on Person CSNK1A1 binds SMO dimer

Class:Id	Reaction:5632671
_displayName	CSNK1A1 binds SMO dimer
_doRelease	TRUE
_timestamp	2014-11-20 02:49:39
authored	[InstanceEdit:5629142] Rothfels, Karen, 2014-10-24
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632669] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
inferredFrom	[Reaction:5632658] Csnk1a1 binds Smo dimer [Mus musculus]
input	[Complex:5632597] SMO dimer [ciliary membrane] [Homo sapiens] [EntityWithAccessionedSequence:5632507] CSNK1A1 [cilium] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5610169] G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila [LiteratureReference:5610283] Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened [LiteratureReference:5610279] Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:5632451] Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase [LiteratureReference:5632444] Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
modified	[InstanceEdit:5636019] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSNK1A1 binds SMO dimer
output	[Complex:5632602] SMO dimer:CSNK1A1 [ciliary membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5632668] SMO translocates to the cilium [Homo sapiens] [Reaction:5632667] SMO dimer binds ARRB and KIF3A [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644896] R-HSA-5632671.2
summation	[Summation:5632403] Activation of SMO in vertebrate cells depends upon its seque...
(hasEvent)	[Pathway:5635838] Activation of SMO [Homo sapiens]
(precedingEvent)	[Reaction:5632670] CSNK1A1 phosphorylates SMO dimer [Homo sapiens]
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No pathways have been reviewed or authored by CSNK1A1 binds SMO dimer (5632671)