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Details on Person SMO translocates to the cilium

Class:Id	BlackBoxEvent:5632668
_displayName	SMO translocates to the cilium
_doRelease	TRUE
_timestamp	2016-03-17 14:48:25
authored	[InstanceEdit:5617420] Rothfels, Karen, 2014-08-06
compartment	[Compartment:24337] endocytic vesicle membrane [Compartment:261122] ciliary membrane
created	[InstanceEdit:5632669] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[Complex:5610574] SMO dimer [endocytic vesicle membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:216183] Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened [LiteratureReference:5610331] Vertebrate Smoothened functions at the primary cilium [LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium [LiteratureReference:5610207] Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium [LiteratureReference:5610270] Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation [LiteratureReference:5610279] Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5628964] Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2 [LiteratureReference:5629104] Beta-arrestin-mediated localization of smoothened to the primary cilium [LiteratureReference:5633029] Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:5610283] Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened [LiteratureReference:5610169] G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila [LiteratureReference:5629130] Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2 [LiteratureReference:5628961] A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia [LiteratureReference:5629140] The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia [LiteratureReference:5629111] EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia [LiteratureReference:5633033] GRK2: multiple roles beyond G protein-coupled receptor desensitization [LiteratureReference:5638098] Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
modified	[InstanceEdit:5633028] Rothfels, Karen, 2014-10-29 [InstanceEdit:5636048] Rothfels, Karen, 2014-11-09 [InstanceEdit:5638125] Rothfels, Karen, 2014-11-13 [InstanceEdit:8864995] Rothfels, Karen, 2016-03-17 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMO translocates to the cilium
output	[Complex:5632597] SMO dimer [ciliary membrane] [Homo sapiens]
precedingEvent	[Reaction:5632667] SMO dimer binds ARRB and KIF3A [Homo sapiens]
regulatedBy	[Requirement:5632690] Requirement by 'SMO dimer:ARRB:KIF3A [endocytic vesicle membrane]' [Requirement:5632691] Requirement by 'Hh-Npp:GAS1:PTCH [ciliary membrane]' [Requirement:5632694] Requirement by 'Hh-Npp:CDON:PTCH [ciliary membrane]' [Requirement:5632696] Requirement by 'Hh-Npp:BOC:PTCH1 [ciliary membrane]' [Requirement:5633056] Requirement by 'GAS8 [cytosol]'
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622857] R-HSA-5632668.4
summation	[Summation:5632415] Binding of ligand to the PTCH receptor activates the Hh sign...
(hasEvent)	[Pathway:5635838] Activation of SMO [Homo sapiens]
(precedingEvent)	[Reaction:5632671] CSNK1A1 binds SMO dimer [Homo sapiens]
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No pathways have been reviewed or authored by SMO translocates to the cilium (5632668)