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Details on Person Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1

Class:Id	Reaction:5632663
_displayName	Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1
_doRelease	TRUE
_timestamp	2014-11-20 02:40:47
authored	[InstanceEdit:5629142] Rothfels, Karen, 2014-10-24
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632662] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[Complex:5632627] pS592, S594, T597, S599-Smo dimer:Csnk1a1 [ciliary membrane] [Mus musculus] [EntityWithAccessionedSequence:5632501] Adrbk1 [cilium] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:5610169] G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila [LiteratureReference:5610283] Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch
modified	[InstanceEdit:5636016] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1
output	[Complex:5632630] pS592, S594, T597, S599-Smo dimer:Csnk1a1:Adrbk1 [ciliary membrane] [Mus musculus]
precedingEvent	[Reaction:5632661] Csnk1a1 phosphorylates Smo dimer [Mus musculus] [Reaction:5632658] Csnk1a1 binds Smo dimer [Mus musculus]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5644565] R-MMU-5632663.2
summation	[Summation:5632408] Ardbk1 binds to the Smo C-terminal tail as assessed by co-im...
(inferredFrom)	[Reaction:5632674] ADRBK1 binds phosphorylated SMO dimer [Homo sapiens]
(precedingEvent)	[Reaction:5632665] Adrbk1 phosphorylates Smo dimer [Mus musculus]
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No pathways have been reviewed or authored by Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1 (5632663)