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Details on Person Shh binds Boc:Ptch1

Class:Id	Reaction:5632654
_displayName	Shh binds Boc:Ptch1
_doRelease	TRUE
_timestamp	2015-06-02 02:06:57
authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5632655] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[Complex:5632586] Boc-Ptch1 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:5362775] Shh(34-?) [extracellular region] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5629141] The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla [LiteratureReference:5629107] Boc is a receptor for sonic hedgehog in the guidance of commissural axons [LiteratureReference:216280] The ihog cell-surface proteins bind Hedgehog and mediate pathway activation [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function [LiteratureReference:208047] Dual roles for patched in sequestering and transducing Hedgehog [LiteratureReference:208217] Biochemical evidence that patched is the Hedgehog receptor [LiteratureReference:208237] The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
modified	[InstanceEdit:5636053] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Shh binds Boc:Ptch1
output	[Complex:5632604] Shh:Boc:Ptch1 [plasma membrane] [Mus musculus]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:6781711] R-MMU-5632654.2
summation	[Summation:5632416] Boc is a co-receptor for Hh signaling that binds both to Ptc...
(inferredFrom)	[Reaction:5632653] Hh-Npp binds BOC:PTCH1 [Homo sapiens]
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No pathways have been reviewed or authored by Shh binds Boc:Ptch1 (5632654)