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Details on Person Hh-Npp binds BOC:PTCH1

Class:Id	Reaction:5632653
_displayName	Hh-Npp binds BOC:PTCH1
_doRelease	TRUE
_timestamp	2014-11-20 02:34:43
authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5632655] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
inferredFrom	[Reaction:5632654] Shh binds Boc:Ptch1 [Mus musculus]
input	[Complex:5632584] BOC:PTCH1 [ciliary membrane] [Homo sapiens] [CandidateSet:5362783] Hh-Npp [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:208047] Dual roles for patched in sequestering and transducing Hedgehog [LiteratureReference:208217] Biochemical evidence that patched is the Hedgehog receptor [LiteratureReference:208237] The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function [LiteratureReference:5629110] Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication [LiteratureReference:5629107] Boc is a receptor for sonic hedgehog in the guidance of commissural axons
modified	[InstanceEdit:5636039] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh-Npp binds BOC:PTCH1
output	[Complex:5632588] Hh-Npp:BOC:PTCH1 [ciliary membrane] [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644350] R-HSA-5632653.2
summation	[Summation:5632424] Hh pathway activation depends upon the binding of Hh ligand ...
(hasEvent)	[Pathway:5632681] Ligand-receptor interactions [Homo sapiens]
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No pathways have been reviewed or authored by Hh-Npp binds BOC:PTCH1 (5632653)