Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Hh-Npp binds CDON and PTCH

Class:Id	Reaction:5632652
_displayName	Hh-Npp binds CDON and PTCH
_doRelease	TRUE
_timestamp	2015-06-02 02:06:57
authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632651] Rothfels, Karen, 2014-10-28
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[CandidateSet:5362783] Hh-Npp [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:197892] CDON [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5610415] PTCH1 [ciliary membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5629138] The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice [LiteratureReference:5629141] The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla [LiteratureReference:5628968] All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner [LiteratureReference:5629124] Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors [LiteratureReference:5629120] Interactions between Hedgehog proteins and their binding partners come into view [LiteratureReference:5629110] Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication [LiteratureReference:5629107] Boc is a receptor for sonic hedgehog in the guidance of commissural axons [LiteratureReference:5629135] The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development [LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
modified	[InstanceEdit:5636040] Rothfels, Karen, 2014-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh-Npp binds CDON and PTCH
output	[Complex:5632590] Hh-Npp:CDON:PTCH [ciliary membrane] [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6781710] R-HSA-5632652.2
summation	[Summation:5632419] CDON is a transmembrane glycoprotein that binds directly to ...
(hasEvent)	[Pathway:5632681] Ligand-receptor interactions [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Hh-Npp binds CDON and PTCH (5632652)