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Details on Person SMURF1/2 ubiquitinates PTCH1

Class:IdReaction:5632648
_displayNameSMURF1/2 ubiquitinates PTCH1
_doReleaseTRUE
_timestamp2015-06-02 02:06:56
authored[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
catalystActivity[CatalystActivity:5632637] ubiquitin protein ligase activity of PTCH1:SMURF [ciliary membrane]
compartment[Compartment:261122] ciliary membrane
created[InstanceEdit:5632647] Rothfels, Karen, 2014-10-28
edited[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
inferredFrom
input[Complex:5632594] PTCH1:SMURF [ciliary membrane] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium
[LiteratureReference:5618035] Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception
[LiteratureReference:5618032] Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover
modified[InstanceEdit:5636051] Rothfels, Karen, 2014-11-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSMURF1/2 ubiquitinates PTCH1
output[Complex:5632582] ub-PTCH1:SMURF [ciliary membrane] [Homo sapiens]
precedingEvent
releaseDate2014-12-11
reviewed[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6781709] R-HSA-5632648.2
summation[Summation:5632439] SMURF 1 and 2 are required in a redundant manner for the lig...
(hasEvent)[Pathway:5632684] Hedgehog 'on' state [Homo sapiens]
(precedingEvent)[Reaction:5635865] SMURF1/2 dissociates from ub-PTCH1 [Homo sapiens]
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No pathways have been reviewed or authored by SMURF1/2 ubiquitinates PTCH1 (5632648)