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Details on Person PRDX1 overoxidizes

Class:Id	Reaction:5631885
_displayName	PRDX1 overoxidizes
_doRelease	TRUE
_timestamp	2022-02-25 02:58:12
authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
catalystActivity	[CatalystActivity:5631899] peroxidase activity of PRDX1 dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5631892] Orlic-Milacic, Marija, 2014-10-27
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
input	[Complex:3341319] PRDX1 dimer [cytosol] [Homo sapiens] [SimpleEntity:29408] H2O2 [cytosol] [SimpleEntity:29408] H2O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5631896] Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid [LiteratureReference:5631886] Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling [LiteratureReference:5631890] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
modified	[InstanceEdit:5662797] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662805] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662822] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5674607] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:8855986] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767215] Rothfels, Karen, 2022-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRDX1 overoxidizes
negativePrecedingEvent	[NegativePrecedingEvent:9767156] Futile Cycle: SRXN1 reduces hyperoxidized PRDX1 dimer
output	[Complex:5631882] HOOS-C52-PRDX1 dimer [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O [Homo sapiens] [Reaction:3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) [Homo sapiens] [Reaction:73646] Regeneration of active (reduced) Thioredoxin [Homo sapiens] [Reaction:73646] Regeneration of active (reduced) Thioredoxin [Homo sapiens] [BlackBoxEvent:9759189] NFE2L2-dependent PRDX1 gene expression [Homo sapiens] [Reaction:9759129] NFE2L2 binds the PRDX1 promoter [Homo sapiens]
releaseDate	2015-03-19
releaseStatus	UPDATED
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679790] R-HSA-5631885.4
summation	[Summation:5631895] The activity of eukaryotic PRDX1 gradually decreases with ti...
(hasEvent)	[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens] [Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9767153] Futile Cycle: PRDX1 overoxidizes [Reaction:5631903] SESN1,2,3 bind overoxidized PRDX1 [Homo sapiens]
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