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Details on Person UniProt:O14929 HAT1
| Class:Id | ReferenceGeneProduct:56301 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-419 added on Sat February 7 2015;initiator methionine:1 for 56301 removed on Fri Nov 03 2023;initiator methionine: for 56301 added on Fri Nov 03 2023;initiator methionine: for 56301 removed on Fri Aug 15 2025;initiator methionine:1 for 56301 added on Fri Aug 15 2025 |
| _displayName | UniProt:O14929 HAT1 |
| _timestamp | 2026-02-20 22:55:15 |
| chain | initiator methionine:1 chain:2-419 |
| checksum | 72DE4146ACC40EF6 |
| comment | FUNCTION Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-methylpropenoyl-CoA (methacryl-CoA), and is able to mediate histone methacrylation (PubMed:34961760).FUNCTION (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell.CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)CATALYTIC ACTIVITY 2-methylpropenoyl-CoA + L-lysyl-[protein] = N(6)-methacrylyl-L-lysyl-[protein] + CoA + H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 4.14 sec(-1) for acetyl-CoA.SUBUNIT Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.INTERACTION Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.ALTERNATIVE PRODUCTS Highly expressed in mitotic cells (at protein level).INDUCTION By viruses and interferons (PubMed:31812350). Up-regulated also by estrogen (PubMed:12841681).PTM Phosphorylated by AMPK at Ser-190; phosphorylation increases HAT1 activity.SIMILARITY Belongs to the HAT1 family.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Histone acetyltransferase entry |
| description | recommendedName: Histone acetyltransferase type B catalytic subunit ecNumber evidence="2 7 15"2.3.1.48 alternativeName: Histone acetyltransferase 1 alternativeName: Histone methacryltransferase HAT1 ecNumber evidence="14"2.3.1.- |
| geneName | HAT1 KAT1 |
| identifier | O14929 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Acyltransferase Alternative splicing Cytoplasm Mitochondrion Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | HAT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992490] ENSEMBL:ENSG00000128708 HAT1 [Homo sapiens] |
| secondaryIdentifier | HAT1_HUMAN Q49A44 Q53QF0 Q53SU4 Q6P594 Q8WWB9 |
| sequenceLength | 419 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965629] UniProt:O14929-1 HAT1 [Homo sapiens] [ReferenceIsoform:8965630] UniProt:O14929-2 HAT1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3662337] HAT1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O14929 HAT1 (56301)
