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Details on Person UniProt:Q92839 HAS1
| Class:Id | ReferenceGeneProduct:56295 |
|---|---|
| _chainChangeLog | chain:1-578 added on Fri February 6 2015;chain:1-578 for 56295 removed on Fri Feb 20 2026;chain:1-577 for 56295 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q92839 HAS1 |
| _timestamp | 2026-05-15 20:05:22 |
| chain | chain:1-577 |
| checksum | 6340521A5A55040B |
| comment | FUNCTION Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential for the synthesis of hyaluronan, a major component of most extracellular matrices that has a structural role in tissue architecture and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).CATALYTIC ACTIVITY [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP + H(+)CATALYTIC ACTIVITY N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + UDP + H(+)COFACTOR Glycan biosynthesis; hyaluronan biosynthesis.INTERACTION Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.SIMILARITY Belongs to the NodC/HAS family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Hyaluronan synthase 1 ecNumber evidence="1"2.4.1.212 alternativeName: Hyaluronate synthase 1 alternativeName: Hyaluronic acid synthase 1 shortName: HA synthase 1 shortName: HuHAS1 |
| geneName | HAS1 HAS |
| identifier | Q92839 |
| isSequenceChanged | FALSE |
| keyword | Glycosyltransferase Membrane Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | HAS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987879] ENSEMBL:ENSG00000105509 HAS1 [Homo sapiens] |
| secondaryIdentifier | HYAS1_HUMAN G3V1S7 Q14470 Q9NS49 |
| sequenceLength | 577 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2142868] HAS1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92839 HAS1 (56295)
