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Details on Person TP53 stimulates expression of SESN1,2,3 genes
Class:Id BlackBoxEvent:5629189
_displayName TP53 stimulates expression of SESN1,2,3 genes
_doRelease TRUE
_timestamp 2016-02-29 20:28:29
authored [InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:5629190] Orlic-Milacic, Marija, 2014-10-24
edited [InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
input [CandidateSet:5629150] SESN1,2,3 Genes [nucleoplasm] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:5629163] PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes [LiteratureReference:5629169] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability [LiteratureReference:5629185] NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation [LiteratureReference:8855971] p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
modified [InstanceEdit:5629196] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5662797] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662805] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662837] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5674607] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:8855969] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8855973] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name TP53 stimulates expression of SESN1,2,3 genes
output [CandidateSet:5629191] SESN1,2,3 [cytosol] [Homo sapiens]
precedingEvent
regulatedBy [PositiveRegulation:5629192] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]'
regulationReference [RegulationReference:9641838] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]' PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
releaseDate 2015-03-19
releaseStatus UPDATED
reviewed [InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:5680179] R-HSA-5629189.5
summation [Summation:5629194] Sestrins (SESN) are a small family of stress-sensitive gene ...
(hasEvent) [Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(precedingEvent) [Reaction:5631903] SESN1,2,3 bind overoxidized PRDX1 [Homo sapiens] [Reaction:5631941] SESN1,2,3 bind AMPK [Homo sapiens]
(updatedInstance) [_UpdateTracker:9783666] Update Tracker - [BlackBoxEvent:5629189] TP53 stimulates expression of SESN1,2,3 genes - v56:[addLiteratureReference, modifyText]
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