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Details on Person TP53 stimulates expression of SESN1,2,3 genes

Class:IdBlackBoxEvent:5629189
_displayNameTP53 stimulates expression of SESN1,2,3 genes
_doReleaseTRUE
_timestamp2016-02-29 20:28:29
authored[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5629190] Orlic-Milacic, Marija, 2014-10-24
edited[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
input[CandidateSet:5629150] SESN1,2,3 Genes [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5629163] PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
[LiteratureReference:5629169] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability
[LiteratureReference:5629185] NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
[LiteratureReference:8855971] p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
modified[InstanceEdit:5629196] Orlic-Milacic, Marija, 2014-10-24
[InstanceEdit:5662797] Orlic-Milacic, Marija, 2015-01-13
[InstanceEdit:5662805] Orlic-Milacic, Marija, 2015-01-13
[InstanceEdit:5662837] Orlic-Milacic, Marija, 2015-01-13
[InstanceEdit:5674607] Orlic-Milacic, Marija, 2015-02-13
[InstanceEdit:8855969] Orlic-Milacic, Marija, 2016-02-08
[InstanceEdit:8855973] Orlic-Milacic, Marija, 2016-02-08
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTP53 stimulates expression of SESN1,2,3 genes
output[CandidateSet:5629191] SESN1,2,3 [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:5629192] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]'
regulationReference[RegulationReference:9641838] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]' PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
releaseDate2015-03-19
releaseStatusUPDATED
reviewed[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30
[InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30
[InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680179] R-HSA-5629189.5
summation[Summation:5629194] Sestrins (SESN) are a small family of stress-sensitive gene ...
(hasEvent)[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(precedingEvent)[Reaction:5631903] SESN1,2,3 bind overoxidized PRDX1 [Homo sapiens]
[Reaction:5631941] SESN1,2,3 bind AMPK [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783666] Update Tracker - [BlackBoxEvent:5629189] TP53 stimulates expression of SESN1,2,3 genes - v56:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by TP53 stimulates expression of SESN1,2,3 genes (5629189)