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Details on Person TP53 stimulates TIGAR expression

Class:Id	BlackBoxEvent:5628901
_displayName	TP53 stimulates TIGAR expression
_doRelease	TRUE
_timestamp	2016-02-29 20:28:28
authored	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:5628895] Orlic-Milacic, Marija, 2014-10-24
edited	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
input	[EntityWithAccessionedSequence:5628852] TIGAR Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5628862] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response [LiteratureReference:8855796] TIGAR, TIGAR, burning bright [LiteratureReference:8855803] Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73
modified	[InstanceEdit:5628915] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5662797] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662805] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5662836] Orlic-Milacic, Marija, 2015-01-13 [InstanceEdit:5674607] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:8855682] Orlic-Milacic, Marija, 2016-02-04 [InstanceEdit:8855799] Orlic-Milacic, Marija, 2016-02-05 [InstanceEdit:8855805] Orlic-Milacic, Marija, 2016-02-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates TIGAR expression
output	[EntityWithAccessionedSequence:5628829] TIGAR [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5628899] TP53 binds the TIGAR gene [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5628903] Positive gene expression regulation by 'TP53 Tetramer:TIGAR Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642556] Positive gene expression regulation by 'TP53 Tetramer:TIGAR Gene [nucleoplasm]' TIGAR, a p53-inducible regulator of glycolysis and apoptosis
releaseDate	2015-03-19
releaseStatus	UPDATED
reviewed	[InstanceEdit:5662800] Hwang, Paul M, 2014-12-30 [InstanceEdit:5662803] Kang, Ju-Gyeong, 2014-12-30 [InstanceEdit:5662801] Wang, Ping-yuan, 2014-12-30 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680326] R-HSA-5628901.5
summation	[Summation:5628896] TIGAR was first identified as a TP53 target through high-thr...
(hasEvent)	[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(precedingEvent)	[Reaction:5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783452] Update Tracker - [BlackBoxEvent:5628901] TP53 stimulates TIGAR expression - v56:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by TP53 stimulates TIGAR expression (5628901)