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Details on Person BRD7 promotes EP300-mediated acetylation of TP53

Class:Id	Reaction:5628871
_displayName	BRD7 promotes EP300-mediated acetylation of TP53
_doRelease	TRUE
_timestamp	2016-02-19 18:19:10
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:5628869] acetyltransferase activity of BRD7:p-S15,S20-TP53:EP300 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644079] acetyltransferase activity of BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] BRD7 is a candidate tumour suppressor gene required for p53 function
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5628867] Orlic-Milacic, Marija, 2014-10-23
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:3222096] BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] [Homo sapiens] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3222107] BRD7 is a candidate tumour suppressor gene required for p53 function
modified	[InstanceEdit:5628877] Orlic-Milacic, Marija, 2014-10-23 [InstanceEdit:5628916] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:6799119] Orlic-Milacic, Marija, 2015-09-21 [InstanceEdit:8847591] Orlic-Milacic, Marija, 2015-12-01 [InstanceEdit:8856585] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRD7 promotes EP300-mediated acetylation of TP53
output	[Complex:5628870] BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] [Homo sapiens] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm]
precedingEvent	[Reaction:3222093] BRD7 binds TP53 and EP300 [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860890] R-HSA-5628871.3
summation	[Summation:5628875] BRD7 promotes EP300 (p300)-mediated acetylation of TP53 on l...
(hasEvent)	[Pathway:5628841] BRD7 Cooperates With TP53 in Transcription Control [Homo sapiens] [Pathway:6804758] Regulation of TP53 Activity through Acetylation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5628884] TP53 and BRD7 positively regulate expression of TP53 targets [Homo sapiens] [Reaction:6805650] MTA2-NuRD complex deacetylates TP53 [Homo sapiens]
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No pathways have been reviewed or authored by BRD7 promotes EP300-mediated acetylation of TP53 (5628871)