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Details on Person SLC26A4 (Pendrin, PDS) can mediate the efflux of iodide (I-)...
| Class:Id | Summation:5627815 |
|---|---|
| _displayName | SLC26A4 (Pendrin, PDS) can mediate the efflux of iodide (I-)... |
| _timestamp | 2025-09-23 09:36:55 |
| created | [InstanceEdit:5627819] Jassal, Bijay, 2014-10-22 |
| modified | [InstanceEdit:9961392] Stephan, Ralf, 2025-07-25 [InstanceEdit:9962424] Stephan, Ralf, 2025-08-04 [InstanceEdit:9966620] Stephan, Ralf, 2025-09-23 |
| text | SLC26A4 (Pendrin, PDS) can mediate the efflux of iodide (I-) from the apical membranes of thyroid cells in exchange for a chloride (Cl-) ion, a function demonstrated in human HEK293 and monkey COS-7 cells (Yoshida et al., 2004; Dossena et al. 2006). SLC26A4 is highly expressed in the adult thyroid and its activity is necessary for production of thyroid hormone (Yoshida et al., 2004; Honda & Griffith, 2022). SLC26A4 is also expressed in the inner ear (Dossena et al. 2006; Honda & Griffith, 2022). Mutations in this gene are associated with Pendred syndrome, an autosomal-recessive disease which is one of the most common forms of syndromic deafness and associated goiter (Dossena et al. 2006; reviewed in Honda & Griffith, 2022). |
| (summation) | [Reaction:5627802] SLC26A4 exports I- to follicular lumen [Homo sapiens] |
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No pathways have been reviewed or authored by SLC26A4 (Pendrin, PDS) can mediate the efflux of iodide (I-)... (5627815)
