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Details on Person TNF-α:TNFR1 binds DENN/MADD

Class:Id	Reaction:5626953
_displayName	TNF-α:TNFR1 binds DENN/MADD
_doRelease	TRUE
_timestamp	2022-06-30 04:20:43
authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5626970] Shamovsky, V, 2014-10-14
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
input	[CandidateSet:5626957] DENN-SV,MADD [cytosol] [Homo sapiens] [DefinedSet:3371401] TNF-α trimer:TNFR1 trimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:5657799] Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3 [LiteratureReference:5657794] IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs [LiteratureReference:5657750] MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells [LiteratureReference:5657803] MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival [LiteratureReference:5657806] MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment
modified	[InstanceEdit:5627604] Shamovsky, V, 2014-10-20 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5633447] Matthews, Lisa, 2014-10-31 [InstanceEdit:5634127] Jassal, Bijay, 2014-11-03 [InstanceEdit:5643755] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5657736] Shamovsky, V, 2014-12-16 [InstanceEdit:5661495] Shamovsky, V, 2015-01-12 [InstanceEdit:5692554] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5693172] Shamovsky, Veronica, 2015-05-14 [InstanceEdit:5693818] Shamovsky, Veronica, 2015-05-18 [InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9794239] Shamovsky, Veronica, 2022-06-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TNF-α:TNFR1 binds DENN/MADD
output	[Complex:5626965] TNF-α:TNFR1:DENN-SV,MADD [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:83660] Membrane-anchored TNF-α binds TNFR1 [Homo sapiens] [Reaction:3371353] Soluble TNF-α binds TNFR1 [Homo sapiens] [Reaction:3371385] TNF-α is cleaved by ADAM17 (TACE) [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796640] R-HSA-5626953.3
summation	[Summation:5657769] MAPK activating death domain (MADD) and DENN-SV are known to...
systematicName	TNF-alpha:TNFR1 binds DENN-SV,MADD
(hasEvent)	[Pathway:5357905] Regulation of TNFR1 signaling [Homo sapiens]
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