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Details on Person GTP-bound RAC1 and CDC42 bind IQGAPs

Class:Id	Reaction:5626469
_displayName	GTP-bound RAC1 and CDC42 bind IQGAPs
_doRelease	TRUE
_timestamp	2015-12-10 04:10:41
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5626466] Orlic-Milacic, Marija, 2014-10-09
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[DefinedSet:5626373] IQGAP [cytosol] [Homo sapiens] [DefinedSet:389778] CDC42:GTP, RAC1:GTP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5626508] Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 [LiteratureReference:5626488] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth [LiteratureReference:5626515] The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration [LiteratureReference:5626520] IQGAP1 is a component of Cdc42 signaling to the cytoskeleton [LiteratureReference:5626541] IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments
modified	[InstanceEdit:5626516] Orlic-Milacic, Marija, 2014-10-10 [InstanceEdit:5626523] Orlic-Milacic, Marija, 2014-10-10 [InstanceEdit:5626548] Orlic-Milacic, Marija, 2014-10-10 [InstanceEdit:5627007] Orlic-Milacic, Marija, 2014-10-14 [InstanceEdit:5627791] Orlic-Milacic, Marija, 2014-10-21 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5634775] Orlic-Milacic, Marija, 2014-11-06 [InstanceEdit:5643681] Orlic-Milacic, Marija, 2014-11-17 [InstanceEdit:5672122] Orlic-Milacic, Marija, 2015-02-04 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674558] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8848626] Orlic-Milacic, Marija, 2015-12-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GTP-bound RAC1 and CDC42 bind IQGAPs
output	[Complex:5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8848618] Activation of RAC1 by the PXN:CRK complex [Homo sapiens] [Reaction:8848611] Phosphorylated PXN recruits the CRK complex [Homo sapiens]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679848] R-HSA-5626469.3
summation	[Summation:5626522] IQGAP proteins IQGAP1, IQGAP2 and IQGAP3, bind Rho GTPases R...
systematicName	RAC1:GTP,CDC42:GTP bind IQGAPs
(hasEvent)	[Pathway:5626467] RHO GTPases activate IQGAPs [Homo sapiens]
(precedingEvent)	[Reaction:5626507] IQGAPs bind F-actin, which is inhibited by calmodulin [Homo sapiens] [Reaction:5626549] IQGAPs bind CALM1 [Homo sapiens] [Reaction:5672329] IQGAP1 binds CLIP1 and microtubules [Homo sapiens]
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No pathways have been reviewed or authored by GTP-bound RAC1 and CDC42 bind IQGAPs (5626469)