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Details on Person CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1

Class:Id	Reaction:5625901
_displayName	CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
_doRelease	TRUE
_timestamp	2017-03-08 18:24:32
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5625891] Orlic-Milacic, Marija, 2014-10-08
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
inferredFrom	[Reaction:5625893] Cit binds activated Rhoa, Rhob, Rhoc and Rac1 [Mus musculus]
input	[DefinedSet:8981458] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] [Homo sapiens] [Complex:5671920] CIT [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5625892] A novel partner for the GTP-bound forms of rho and rac
modified	[InstanceEdit:5625913] Orlic-Milacic, Marija, 2014-10-08 [InstanceEdit:5627007] Orlic-Milacic, Marija, 2014-10-14 [InstanceEdit:5627791] Orlic-Milacic, Marija, 2014-10-21 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5643681] Orlic-Milacic, Marija, 2014-11-17 [InstanceEdit:5671924] Orlic-Milacic, Marija, 2015-02-03 [InstanceEdit:5671999] Orlic-Milacic, Marija, 2015-02-03 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674556] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8848626] Orlic-Milacic, Marija, 2015-12-10 [InstanceEdit:8981451] Orlic-Milacic, Marija, 2017-03-08 [InstanceEdit:8981463] Orlic-Milacic, Marija, 2017-03-08 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
output	[Complex:5625899] RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8848618] Activation of RAC1 by the PXN:CRK complex [Homo sapiens] [Reaction:8848611] Phosphorylated PXN recruits the CRK complex [Homo sapiens]
regulatedBy	[NegativeRegulation:8981455] Negative regulation by 'CIT:CDKN1B [cytosol]'
regulationReference	[RegulationReference:9642192] Negative regulation by 'CIT:CDKN1B [cytosol]' p27(Kip1) controls cytokinesis via the regulation of citron kinase activation
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679914] R-HSA-5625901.6
summation	[Summation:5625911] Citron kinase CIT was identified as a RHO GTPase effector in...
systematicName	CIT binds RHO GTPases
(hasEvent)	[Pathway:5625900] RHO GTPases activate CIT [Homo sapiens]
(precedingEvent)	[Reaction:5671919] Activated CIT phosphorylates MRLCs [Homo sapiens] [Reaction:5671970] Activated CIT binds KIF14 and PRC1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781414] Update Tracker - [Reaction:5625901] CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 - v61:[addRegulator, add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (5625901)