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Details on Person PKN1 in complex with AR positively regulates expression of KLK2 and KLK3

Class:Id	BlackBoxEvent:5625883
_displayName	PKN1 in complex with AR positively regulates expression of KLK2 and KLK3
_doRelease	TRUE
_timestamp	2015-03-04 03:56:41
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment	[Compartment:984] extracellular region [Compartment:7660] nucleoplasm
created	[InstanceEdit:5625880] Orlic-Milacic, Marija, 2014-10-08
edited	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24
input	[DefinedSet:5625769] KLK2,3 genes [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
modified	[InstanceEdit:5627007] Orlic-Milacic, Marija, 2014-10-14 [InstanceEdit:5627292] Orlic-Milacic, Marija, 2014-10-17 [InstanceEdit:5627791] Orlic-Milacic, Marija, 2014-10-21 [InstanceEdit:5632708] Matthews, Lisa, 2014-10-28 [InstanceEdit:5633087] Jassal, Bijay, 2014-10-30 [InstanceEdit:5643681] Orlic-Milacic, Marija, 2014-11-17 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674555] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5678309] Orlic-Milacic, Marija, 2015-02-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PKN1 in complex with AR positively regulates expression of KLK2 and KLK3
output	[DefinedSet:5625882] KLK2,KLK3 [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters [Homo sapiens] [Reaction:5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters [Homo sapiens]
regulatedBy	[PositiveRegulation:5625881] Positive regulation by 'p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm]'
regulationReference	[RegulationReference:9642891] Positive regulation by 'p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm]' Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679919] R-HSA-5625883.4
summation	[Summation:5627291] PKN1-facilitated demethylation of histones at promoters of K...
systematicName	KLK2,3 genes express KLK2,3 proteins
(hasEvent)	[Pathway:5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 [Homo sapiens]
(precedingEvent)	[Reaction:381466] Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS [Homo sapiens] [BlackBoxEvent:1592398] Activation of proMMP8 [Homo sapiens] [Reaction:1604722] Activation of proMMP9 by proteases [Homo sapiens]
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No pathways have been reviewed or authored by PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (5625883)