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Details on Person PKN1-mediated phosphorylation of histone H3 threonine residu...
| Class:Id | Summation:5625877 |
|---|---|
| _displayName | PKN1-mediated phosphorylation of histone H3 threonine residu... |
| _timestamp | 2014-10-08 15:46:45 |
| created | [InstanceEdit:5625873] Orlic-Milacic, Marija, 2014-10-08 |
| text | PKN1-mediated phosphorylation of histone H3 threonine residue T12 (also labeled in literature as Thr11) enables demethylation of histone H3 lysine K10 (also labeled in literature as K9) by demethylase KDM1A (LSD1) (Metzger et al. 2008). KDM1A acts on dimethylated and monomethylated H3K9 at AR-regulated promoters (Metzger et al. 2005), so it is shown that KDM1A-mediated demethylation of monomethylated H3K9 (MeK-10-H3) happens sequentially after KDM1A-mediated demethylation of dimethylated H3K9 (Me2K-10-H3). |
| (summation) | [Reaction:5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters [Homo sapiens] |
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No pathways have been reviewed or authored by PKN1-mediated phosphorylation of histone H3 threonine residu... (5625877)
