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Details on Person SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol

Class:Id	FailedReaction:5625029
_displayName	SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2022-02-21 16:21:32
authored	[InstanceEdit:5625030] Jassal, Bijay, 2014-10-01
catalystActivity	[CatalystActivity:9631826] high-affinity L-glutamate transmembrane transporter activity of SLC1A1 mutants [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5625030] Jassal, Bijay, 2014-10-01
disease	[Disease:5625037] amino acid metabolic disorder [Disease:5625048] schizophrenia
edited	[InstanceEdit:5625030] Jassal, Bijay, 2014-10-01
entityFunctionalStatus	[EntityFunctionalStatus:5625042] loss_of_function of SLC1A1 mutants [plasma membrane]
input	[SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:29804] K+ [cytosol] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [DefinedSet:428027] L-Glu,L-Asp,D-Asp [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:5625009] Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria [LiteratureReference:5625019] Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies [LiteratureReference:5625011] Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family [LiteratureReference:5625016] Glutamate as a neurotransmitter in the healthy brain
modified	[InstanceEdit:5625241] Jassal, Bijay, 2014-10-03 [InstanceEdit:6789777] Jassal, Bijay, 2015-08-04 [InstanceEdit:9631717] Wu, G, 2018-12-12 [InstanceEdit:9766405] D'Eustachio, Peter, 2022-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
normalReaction	[Reaction:428015] SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797138] R-HSA-5625029.4
summation	[Summation:5625007] There are two classes of glutamate transporters; the excitat...
(hasEvent)	[Pathway:5619067] Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775079] Update Tracker - [FailedReaction:5625029] SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol - v80:[addLiteratureReference, modifyText] [_UpdateTracker:9778244] Update Tracker - [FailedReaction:5625029] SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol - v68:[addCatalystActivity]
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