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Details on Person Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit

Class:Id	Reaction:5624473
_displayName	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
_doRelease	TRUE
_timestamp	2015-03-04 04:00:45
authored	[InstanceEdit:5660664] Garapati, P V, 2015-01-04
catalystActivity	[CatalystActivity:5624489] protein serine/threonine kinase activity of RPS6KA5(MSK1/SAPK1):PKA catalytic subunits [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643049] protein serine/threonine kinase activity of RPS6KA5(MSK1/SAPK1):PKA catalytic subunits [nucleoplasm] Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5624475] Garapati, P V, 2014-09-29
edited	[InstanceEdit:5660664] Garapati, P V, 2015-01-04
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:194047] NFKB1(1-433):RELA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660562] Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation [LiteratureReference:5660629] Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1) [LiteratureReference:5660578] Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype [LiteratureReference:5607189] C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB [LiteratureReference:5607468] Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
modified	[InstanceEdit:5660667] Garapati, P V, 2015-01-04 [InstanceEdit:5660979] Garapati, P V, 2015-01-07 [InstanceEdit:5674204] Garapati, P V, 2015-02-11 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
output	[Complex:5624488] NFKB1:p-S276-RELA [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:5624486] SFKs phosphorylates RAF1 on Y340,Y341 [Homo sapiens] [Reaction:5624492] PAK phosphorylates p21 RAF1 on S338 [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680002] R-HSA-5624473.3
summation	[Summation:5624482] Protein kinase A (PKA/PRKACA) and Ribosomal protein S6 kinas...
(hasEvent)	[Pathway:5621575] CD209 (DC-SIGN) signaling [Homo sapiens] [Pathway:8852558] Transcriptional Regulation by the NFKB Complex [Homo sapiens]
(precedingEvent)	[Reaction:5660666] CBP and p300 binds NF-kB complex [Homo sapiens] [Reaction:5660980] p-S276-RELA binds RELB [Homo sapiens]
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No pathways have been reviewed or authored by Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (5624473)