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Details on Person PDPK1 phosphorylates PKN1,2,3

Class:Id	Reaction:5623667
_displayName	PDPK1 phosphorylates PKN1,2,3
_doRelease	TRUE
_timestamp	2015-03-04 04:06:35
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5623661] protein serine/threonine kinase activity of RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5623666] Orlic-Milacic, Marija, 2014-09-18
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[Complex:5623637] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5623634] Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase [LiteratureReference:5623676] Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1 [LiteratureReference:5623665] Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1)
modified	[InstanceEdit:5624297] Orlic-Milacic, Marija, 2014-09-23 [InstanceEdit:5624316] Orlic-Milacic, Marija, 2014-09-24 [InstanceEdit:5624317] Orlic-Milacic, Marija, 2014-09-24 [InstanceEdit:5627007] Orlic-Milacic, Marija, 2014-10-14 [InstanceEdit:5627286] Orlic-Milacic, Marija, 2014-10-17 [InstanceEdit:5627791] Orlic-Milacic, Marija, 2014-10-21 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5643681] Orlic-Milacic, Marija, 2014-11-17 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674555] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PDPK1 phosphorylates PKN1,2,3
output	[CandidateSet:5623659] p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [Complex:377179] PDPK1:PIP3 [plasma membrane] [Homo sapiens] [Complex:5624294] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 [Homo sapiens] [Reaction:5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 [Homo sapiens] [Reaction:8848618] Activation of RAC1 by the PXN:CRK complex [Homo sapiens]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680099] R-HSA-5623667.2
summation	[Summation:5624315] PDPK1 (PDK1) phosphorylates PKN1, PKN2 and likely PKN3 on a ...
systematicName	Complexed PDPK1 phosphorylates complexed PNK1-3
(hasEvent)	[Pathway:5625740] RHO GTPases activate PKNs [Homo sapiens] [Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
(precedingEvent)	[Reaction:5625717] Phosphorylated PKN1 binds androgen receptor (AR) [Homo sapiens] [Reaction:5671737] p-T774-PKN1 binds CDC25C [Homo sapiens] [Reaction:5671763] p-T774-PKN1 phosphorylates PPP1R14A [Homo sapiens]
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No pathways have been reviewed or authored by PDPK1 phosphorylates PKN1,2,3 (5623667)