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Details on Person RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3

Class:Id	Reaction:5623622
_displayName	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
_doRelease	TRUE
_timestamp	2015-03-04 04:21:06
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5623620] Orlic-Milacic, Marija, 2014-09-17
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[CandidateSet:5623626] PKN1-3 [cytosol] [Homo sapiens] [Complex:5624294] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5623615] Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB [LiteratureReference:5623625] Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1 [LiteratureReference:5623619] The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1 [LiteratureReference:5624312] Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1) [LiteratureReference:5624309] The Rac1 polybasic region is required for interaction with its effector PRK1 [LiteratureReference:5624305] Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation
modified	[InstanceEdit:5623630] Orlic-Milacic, Marija, 2014-09-17 [InstanceEdit:5624297] Orlic-Milacic, Marija, 2014-09-23 [InstanceEdit:5624299] Orlic-Milacic, Marija, 2014-09-24 [InstanceEdit:5624313] Orlic-Milacic, Marija, 2014-09-24 [InstanceEdit:5627007] Orlic-Milacic, Marija, 2014-10-14 [InstanceEdit:5627791] Orlic-Milacic, Marija, 2014-10-21 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5643681] Orlic-Milacic, Marija, 2014-11-17 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674555] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
output	[Complex:5623624] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] [Homo sapiens]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680341] R-HSA-5623622.2
summation	[Summation:5623628] Each protein kinase C related kinase - PKN1 (PRK1), PKN2 (PR...
systematicName	RHO GTPases bind PKN1-3
(hasEvent)	[Pathway:5625740] RHO GTPases activate PKNs [Homo sapiens] [Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
(precedingEvent)	[Reaction:5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 [Homo sapiens]
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No pathways have been reviewed or authored by RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (5623622)