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Details on Person UniProt:P62806 H4c1
| Class:Id | ReferenceGeneProduct:56223 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-103 added on Sat February 7 2015;initiator methionine:1 for 56223 removed on Fri Nov 03 2023;initiator methionine: for 56223 added on Fri Nov 03 2023;initiator methionine: for 56223 removed on Fri Aug 15 2025;initiator methionine:1 for 56223 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62806 H4c1 |
| _timestamp | 2026-02-20 21:30:34 |
| chain | initiator methionine:1 chain:2-103 |
| checksum | A9E5DFD3F8B97598 |
| comment | FUNCTION Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with NASP; NASP is a histone chaperone that stabilizes and maintains a soluble pool of Histone H3-H4 dimers (By similarity).INTERACTION Localized to the nucleus when acetylated in step 11 spermatids.TISSUE SPECIFICITY Expressed in step 11 and 12 spermatids (at protein level).PTM Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Acetylated as part of spermatogenesis progression prior to histone-to-protamine exchange (PubMed:32726616).PTM Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.PTM Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).PTM Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by KMT5A/SET8 (By similarity). Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (PubMed:24049080). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (By similarity). H4K20me2 and H4K20me3 are demethylated into monomethyl (H4K20me1) by RSBN1 (PubMed:34185806). H4K20me1, H4K20me2 and H4K20me3 are demethylated by RAD23A and RAD23B (By similarity). H4K20me1 is demethylated by PHF8 (By similarity).PTM Acetyl-methylated at Lys-6 and Lys-13 (H4K5acme and H4K12acme, respectively), acetyl-methylation is an epigenetic mark of active chromatin associated with increased transcriptional initiation. Acetyl-methylation is formed by acetylation by EP300/p300 of lysine residues that are already monomethylated on the same side chain. H4K5acme and H4K12acme marks specifically bind BRD2.PTM Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).PTM Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity). Ubiquitinated; by PHF7 (PubMed:32726616).PTM Sumoylated, which is associated with transcriptional repression.PTM Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.PTM Hydroxybutyrylation of histones is induced by starvation.PTM Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.PTM Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.PTM Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.PTM Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. Delactylated by SIRT3 at Lys-17 (H4K16la).SIMILARITY Belongs to the histone H4 family. |
| description | recommendedName: Histone H4 |
| geneName | H4c1 Hist1h4a H4c2 H4-53 Hist1h4b H4c3 H4-12 Hist1h4c H4c4 Hist1h4d H4c6 Hist1h4f H4c8 Hist1h4h H4c9 Hist1h4i H4c11 Hist1h4j H4c12 Hist1h4k Hist1h4m H4c14 Hist2h4 Hist2h4a H4c16 H4f16 Hist4h4 |
| identifier | P62806 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Chromosome Citrullination DNA-binding Hydroxylation Isopeptide bond Methylation Nucleosome core Nucleus Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | H4c1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | H4_MOUSE A0AUM5 A4FUP8 A4QMY0 P02304 P02305 Q0VDL9 Q2M2Q5 Q5T006 Q6PDS7 Q811M0 Q9D0C9 Q9D6Q8 |
| sequenceLength | 103 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:573367] AcK6,9,17-Hist1h4a [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:573379] Histone H4 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:4568959] AcK9-histone H4 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9960080] AcK17-Hist1h4a [nucleoplasm] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:573323] N6-acetyl-L-lysine at 9 [ModifiedResidue:573361] N6-acetyl-L-lysine at 6 [ModifiedResidue:573388] N6-acetyl-L-lysine at 17 [ModifiedResidue:4568923] N6-acetyl-L-lysine at 9 |
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No pathways have been reviewed or authored by UniProt:P62806 H4c1 (56223)
