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Details on Person Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone...
| Class:Id | Summation:5622020 |
|---|---|
| _displayName | Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone... |
| _timestamp | 2014-09-08 17:14:07 |
| created | [InstanceEdit:5622022] Jassal, Bijay, 2014-09-08 |
| text | Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone hydroxylase) is an enzyme necessary for aldosterone biosynthesis via corticosterone (CORST) and 18-hydroxycorticosterone (18HCORST). Defects in CYP11B2 results in disorders of aldosterone synthesis. Corticosterone methyloxidase 1 and 2 deficiencies (CMO-1; MIM:203400 and CMO-2 deficiency; MIM:61060) are autosomal recessive disorders of aldosterone biosynthesis (Mitsuuchi et al. 1993, Bureik et al. 2002). In CMO-1 deficiency, aldosterone is undetectable in plasma, while its immediate precursor, 18HCORST, is low or normal. In CMO-2 deficiency, aldosterone can be low or normal, but at the expense of increased secretion of 18HCORST. Patients with CMO-2 deficiency have elevated plasma 18-hydroxycorticosterone/aldosterone ratios. |
| (summation) | [Pathway:5579009] Defective CYP11B2 causes CMO-1 deficiency [Homo sapiens] |
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No pathways have been reviewed or authored by Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone... (5622020)
