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Details on Person Defective GCK does not phosphorylate Glc to form G6P
| Class:Id | FailedReaction:5621918 |
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| _displayName | Defective GCK does not phosphorylate Glc to form G6P |
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| _doRelease | TRUE |
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| _timestamp | 2015-09-04 20:50:17 |
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| authored | [InstanceEdit:5621911] Jassal, Bijay, 2014-09-05 |
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| catalystActivity | [CatalystActivity:9631837] glucokinase activity of GCK mutants [cytosol] |
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| compartment | [Compartment:70101] cytosol |
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| created | [InstanceEdit:5621911] Jassal, Bijay, 2014-09-05 |
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| disease | [Disease:5623598] maturity-onset diabetes of the young |
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| edited | [InstanceEdit:5621911] Jassal, Bijay, 2014-09-05 |
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| entityFunctionalStatus | [EntityFunctionalStatus:5621901] loss_of_function of GCK mutants [cytosol] |
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| input | [SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:70113] Glc [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:5621858] Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
[LiteratureReference:5621854] Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
[LiteratureReference:500021] Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus
[LiteratureReference:5621859] Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients
[LiteratureReference:5621884] Insight into the biochemical characteristics of a novel glucokinase gene mutation |
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| modified | [InstanceEdit:5623578] Jassal, Bijay, 2014-09-17
[InstanceEdit:5623756] Jassal, Bijay, 2014-09-19
[InstanceEdit:6789777] Jassal, Bijay, 2015-08-04
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective GCK does not phosphorylate Glc to form G6P |
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| normalReaction |
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| releaseDate | 2015-09-22 |
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| releaseStatus | NEW |
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| reviewed | [InstanceEdit:6789776] Broer, Stefan, 2015-08-04 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:6797128] R-HSA-5621918.3 |
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| summation | [Summation:5621904] Cytosolic glucokinase (GCK) (as well as three isoforms of he... |
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| (hasEvent) | [Pathway:5619073] Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) [Homo sapiens] |
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| (updatedInstance) | [_UpdateTracker:9778073] Update Tracker - [FailedReaction:5621918] Defective GCK does not phosphorylate Glc to form G6P - v68:[addCatalystActivity] |
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